A Flexible ATP Bioluminescence™ In Vitro Toxicity Assay Platform for Multiple Cell Types.
Uses of StemGlo™-Tox HT
High throughput in vitro toxicity screening and testing of multiple cell types with multiplexing capability.
Can be incorporated at any stage of drug development, including ADME/Tox.
Drug/agent toxicity ranking according to cell source and species.
Benefits of using STEMGlo™-Tox HT
A flexible, in vitro assay platform to perform high throughput toxicity testing.
Can be applied to numerous cell types derived from different organs, tissues and species.
High-throughput capability using 96- or 384-well plate formats allows ADME-Tox drug or compound screening, thereby significantly reducing unexpected results during pre-clinical testing.
Available for adherent or non-adherent cell types.
2D and 3D cell culture models.
STEMGlo™-Tox HT is part of the ComparaTox™ 1 Platform to compare and rank toxicities from different organs, tissues and species. (Please see separate information flyer).
Incorporates the most sensitive ATP bioluminescence readout available to measure proliferation, cytotoxicity, cell number and even apoptosis.
All assay kits include standards and controls to calibrate and standardize the assay prior to measuring samples.
Validated signal detection readout according to FDA Bioanalytical Method Guidelines.
Allows results to be compared over time.
Results usually in 4 to 5 days depending on species and cell type.
Designed for multiplexing with other assay using the same sample.
STEMGlo™-Tox HT assay kits include everything required to perform the assay, except cells.
STEMGlo™-96 PRT detects predictive residual toxicity after a single dose.
All assays are fast to learn and easy to use and implement.
A 3Rs Assay Platform-Helps Reduction, Refinement, Replacement for animal testing.
Cell Types for use with STEMGlo™-Tox HT
STEMGlo™-Tox HT can be used with cell types from the following organs and tissues:
Other cell types include:
Proliferating cell lines
Embryonic stem (ES) cells
Induce pluripotent stem (iPS) cells
For hepatotoxicity and neurotoxicity, specific assays are available. See HepatoGo™-Tox HT and NeutoGlo™-Tox HT.
In vitro toxicity screening and testing using either 96- or 384-well plates
For Research Use Only. Not for clinical diagnostic use.
Major Equipment Required
Plate luminometer or multiparameter plate reader with "glow" luminescence measuring capability.
ATP Enumeration Reagent
Sterile, 96- or 384-well plates, depending on assay use
Non-sterile, 96- or 384-well plates, depending on assay use
Sterile, adhesive foil covers to maintain sterility of unused wells
In Vitro Toxicity Assay Platform for Multiple Cell Types
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